EEG Coherence Analysis for Suppression of MEP Amplitude Variability in TMS

Keisuke Sasaki, Yuki Fujishige, Masato Odagaki


Transcranial magnetic stimulation (TMS) is a non-invasive stimulation method for cortical neurons. When TMS is delivered to the primary motor cortex (M1), motor evoked potentials can be measured in electromyograms for the peripheral muscle. However, the motor-evoked potential (MEP) amplitudes measured by stimulations for M1 fluctuated from trial to trial. MEP fluctuations are caused by changes in cortical excitability. We hypothesized that MEP variability could be suppressed with application of TMS when cortical excitability was stable. Thus, we developed a TMS system to suppress MEP amplitude variabilities. We used electroencephalographic (EEG) online measurements with coherence analysis to obtain the similarity of cortical excitabilities. The system enables us to trigger TMS if the EEGs measured from the two channels have a high similarity in the frequency domain. In this study, we found that the suppression of MEP fluctuation was dependent on the state of cortical excitability obtained by EEG coherence analysis.


motor evoked potential; transcranial magnetic stimulation; coherence analysis; cortical excitability; frequency analysis

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International Journal of Online and Biomedical Engineering (iJOE) – eISSN: 2626-8493
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